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High Quality Estrogen Raw Steroids Powder Melengestrol Acetate for Anti Cancer CAS 2919-66-6
High Quality Estrogen Raw Steroids Powder Melengestrol Acetate for Anti Cancer CAS 2919-66-6
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0 Gram/Grams per 0
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Quick Details
Place of Origin:
China (Mainland)
Brand Name:
Pharmlab
Model Number:
2919-66-6
Packaging & Delivery
Disguised package; Foil bag
Product Description

High Quality Estrogen Raw Steroids Powder Melengestrol Acetate for Anti Cancer CAS 2919-66-6 


Basic Info


CAS No.: 2919-66-6

Suitable for: Adult

Purity: >99%

EINECS: 220-859-7

M.W.: 396.52

M.F.: C25h32o4

Trademark: Pharmlab

HS Code: 3001200020

Certification: ISO 9001, USP, GMP

Appearance: Light Yellow Crystalline Powder

Usage: Female hormone

Density: 1.15 g/cm3

Melting Point: 202-204 ° C(lit. )

Boiling Point: 516.1 ° C at 760 mmHg

Flash Point: 221.7 ° C

Origin: China


Description:


Melengestrol acetate (INN, USAN), sometimes abbreviated as MGA, is a steroidal progestin and antineoplastic agent.It is not approved for use in humans, and is instead used as a feed additive to promote growth in cattle, a purpose it is licensed for in the United States and Canada.It is an acetate ester of melengestrol, which in contrast, is not used in either animals or humans.


Melengestrol acetat is widely used as a growth promoting feed additive in cattle breeding in the USA and several other non-European countries. To explore the physiological effects of MGA four heifers were fed during 8 weeks with 0.5 mg MGA daily as registered in the USA and two heifers each received 0, 1.5 or 5 mg/day, respectively. Plasma samples were collected twice a week and concentrations of MGA, progesterone and estradiol-17beta were quantified. The pulsatile secretion of luteinizing hormone was investigated in 6-hour profiles before and during treatment. After slaughter the reproductive organs were examined and oestrogen residues in edible tissues were measured.

 

Four days after the beginning of MGA feeding MGA concentrations in plasma reached levels of 30 and 100-400 pg/mL depending on the dose received. Three weeks after the beginning of MGA feeding P4 plasma concentrations had dropped to base levels below 0.3 ng/mL in all three treatment groups. Mean plasma E2-17beta levels increased in physiological range from 1 to 5 pg/mL during 0.5 mg MGA/day feeding with many acyclic peaks. Overdosed MGA decreased E2 levels and suppressed cyclic peaks. Number and size of ovarian follicles were not altered by any treatment. Mean LH levels and pulse frequencies increased significantly during labelled treatment , while higher doses had reducing effects. The development of corpus luteum was suppressed. E2-17beta residues in fat increased about 300% following labelled MGA treatment.


Application:


To investigate the relation of ovarian morphology to increased body weight gain during administration of melengestrol acetate, ovaries of 100 Holstein dairy heifers were examined for characteristics of follicular maturation, signs of lipid secretion, and the presence of steroid-producing-type cell organelles. The heifers were fed either a normal or a high-protein level ration with or without 0.30-0.45 mg daily of MGA from 2.5 months of age to the age of first estrus or to breeding age. The high-level ration effect was not consistently mediated by the special development of ovarian structures.

 

MGA effect, like the weight-gain effect, was consistently evident after the time of first estrus. MGA suppressed estrus and ovulation, and resulted in the presence in the ovary, after regression of corpora lutea, of an increased number of large follicles. The largest follicles corresponding in structure to developing proestrous, mature estrous, or early atretic follicles contained hypertrophied theca interna cells showing lipid secretion signs and ultrastructural characteristics of steroid synthesis. The majority of the largest follicles, however, were atretic or late atretic and did not contain steroid-type cells. The development of replacement follicles was evident in ovaries with late atretic largest follicles. The weight-gain effect of MGA may therefore be associated with a steroidogenic, probably estrogenic, effect in the cow.


The use of steroid hormone analogues in animals used for human consumption has been a 

source of international debate for many years. In the European Union, a total ban of anabolic agents 

for growth promotion in food animals has been in place since 1988 on the bases of unknown or poorly 

demonstrated food safety (Stephany 2001). After a review of 17 scientific studies by the Scientific 

Committee on Veterinary Measures Relating to Public Health, the European Commission concluded that 

hormonally-treated meat poses a risk to consumers (SCVPH 2002). Conversely, in Canada and the USA, 

certain synthetic and natural anabolic steroid hormones are approved for use under controlled 

regulations (Stephany 2001). Interestingly, after a review of the same 17 studies, Health Canada 

concluded that residues in beef pose no undue risk to human health, provided the drugs are used and 

administered appropriately



Packaging & Delivery


Sufficient stock

Sophisticated and professional logistic agent.

Well-trained and disciplined packing team.

Packing pictures and tacking code are provided within 12 hours after receiving the payment.

Excellent after-sale service: Any questions or problems after receiving the product, please feel free to 

contact us. Problems would be solved immediately.


Competitive Advantages:


Rich experience

We specialize in this field for many years,our pharmaceutical raw materials exported to Overseas, to Europe,Africa,Asia, Americas and other country, and we have got very good feedback from our customers,and Established long friendly relations of cooperation.

Great quality, purity and favorable.

Good quality is one of our secret success, welcome order the samples.

Safest and fastest delivery

We have Adequate stock,and can arranged within 24 hours when receive the payment.Tracking number would be informed quickly after shipment.

We have special way could ship 2kg to 20tons products a time. We offer melting powder into liquid service.And ship the liquid in special bottles.

Good after-sales service

Tell the package update asap, and will try best solve when customer encountered various problems!

Everything is for customers

Our products and services will focus on the largest customer demand,We hold the greatest enthusiasm and sincere cooperation with each customer.

All in all, high quality, best service, security shipping and competitive price are our perpetual pursuance.


Price negotiable.


If there are any questions, please feel free to contact me.

Email:gcyj120@ycphar.com

Whatsapp:+8615308670259


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